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even small temperature excursions accumulate across weeks of active use, and careful logging makes it straightforward to correlate experimental drift with material handling

Mol Cell Endocrinol (2021) 528:111239

Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure

Ask things like: What tests are needed to find out why Im having balance problems