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Paradoxically, this increase has been associated with improved all-cause mortality as well as cardiovascular mortality, according to a post hoc analysis of the PROactive trial (259)

1 The SUSTAIN-2 trial demonstrated that adding semaglutide to metformin reduced HbA1c by 1.3-1.6% and led to weight loss of 4.3-6.1 kg over 56 weeks, compared to just 0.5% HbA1c reduction and 1.9 kg weight loss with sitagliptin added to metformin