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Glutathione peroxidase (GPx) is an enzyme with peroxidase activity whose main biological role is to protect the cell from oxidative damage by reducing lipid hydroperoxides to their corresponding alcohols and reducing free hydrogen peroxide to water [21]

It has shown strong anti-proliferative and anti-metastatic effects in vitro and in vivo and also reduced the production of inflammatory cytokines such as IL-6 and TNF- thus suggesting it to be an important therapeutic agent against cancer progression

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Clinical complications, such as liver cirrhosis, hepatocellular carcinoma, diabetes, cardiomyopathy, hypogonadism, arthropathy, and osteoporosis, may occur [65]