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Reported Effects Glycemic control: As an adjunct to insulin, pramlintide produced a modest HbA1c reduction (on the order of a few tenths of a percentage point) versus placebo over 52 weeks in both type 1 and type 2 diabetes [3] [4]

More recent agents include dual agonists such as tirzepatide, which activates both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors and produces even greater weight loss

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