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6.6 Incretin Receptor Activation Reduces the Chronic Inflammation Response GLP-1 receptor agonists have shown clear anti-inflammatory effects [116, 166]
The utility of this stimuli-responsive platform is demonstrated through two complementary in vivo applications: tumor-targeted prodrug activation triggered by the reductive tumor microenvironment in a 4T1 breast cancer model, and repeatable, on-demand local anesthesia controlled by 405 nm light
Orforglipron's signaling profile has been characterized in the peer-reviewed publication in Science Translational Medicine in 2024, which reported that orforglipron demonstrates a Gs-biased signaling profile with relatively reduced beta-arrestin recruitment compared to peptide agonists
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