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the other is that excessive lipid peroxidation leads to the thinning and the increased curvature of the membrane, resulting in membrane instability and micelle formation, eventually causing ferroptotic cell death ( PUFAs in the phospholipids (PLs) of cell membranes, rather than mono-unsaturated FA, cholesterol, and cardiolipin, are highly prone to lipid peroxidation (Yang et al., 2016)

Sedating Antihistamines (Diphenhydramine/Doxylamine) Mechanism: Antihistamines block H1 receptors, causing drowsiness

It converts the superoxide radical into hydrogen peroxide and oxygen 25

Ultimately, they found no statistically significant improvements in total clinician-rated scores but saw trends towards improvement in patients taking Avmacol