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*Certain medications can increase oxidative stress , place a higher demand on detox pathways, or interfere with the bodys ability to produce and recycle glutathione

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showed that Mn injections for 6 weeks reduced superoxide dismutase, catalase, and glutathione (GSH) activity ( in vivo (Morello et al., 2007) and in dopamine neurons (Neely et al., 2017) and SH-SY5Y cells in vitro (Maddirala et al., 2015)