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(2018) 175:488501.e22

Tang Z, Yu S, Pan Y (2023) The gut microbiome tango in the progression of chronic kidney disease and potential therapeutic strategies

In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]

The hormone suppresses postprandial glucagon secretion, reducing hepatic glucose production when its not needed