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Tesamorelin is the most clinically validated option for visceral fat reduction, with FDA approval and robust trial data backing it

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Therefore, the conjunction of the immune checkpoint inhibitors to modulators of lipid peroxidation can have additive effect on immune responses and on the impact on tumour [278]

The mechanisms underlying these potential synergistic effects remain under active investigation and may involve growth factor signaling, extracellular matrix synthesis, or anti-catabolic pathways in joint tissues