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Studies carried out in a human myeloma cell line have found that phenylhexyl ITC induced histone H3 hyperacetylation and demethylation of the aberrantly methylated p16 promoter in a concentration-dependent manner, suggesting that phenylhexyl ITC has dual epigenetic modulating effects on both DNA methylation and chromatin ( Reference Lu, Lin and Feng 55 )

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doi: 10.1016/j.ccell.2019.04.002 58 KinowakiYKurataMIshibashiSIkedaMTatsuzawaAYamamotoMet al

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doi: 10.3390/medicina57101030 34 MaesMTwiskFNM

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