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For example, vitamin B12 is necessary for the production of DNA and red blood cells

APEX1 inhibitors induce cell death, such as apoptosis and pyroptosis [124], while iron significantly inhibits APEX1 activity, exacerbating the damage to cells caused by oxidative stress [125]

Upadhyayula, P

[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis