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He only works sparingly in front of the camera these days, but I think he still has it particularly in The Old Man and the Gun with Sissy Spacek, A Walk in the Woods with Nick Nolte, and his solo tour de force All is Lost. He has never been afraid to be a flawed anti-hero (Downhill Racer) or an all-out bad guy (spoiler alert: Captain America: The Winter Soldier.) The on-screen pairings have been high points so memorable as Denys with Meryl Streep in Out of Africa. A good move was working with Brad Pitt in Spy Game, and he coaxed a career-best performance (at the time) from Pitt in A River Runs Through It, which he directed and narrated

doi: 10.1186/s12971-014-0023-6

Dara Adams, M.D., and Jerry Krishnan, MD, PhD, at the University of Illinois Chicago