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Confirming normal baseline organ function is a mandatory pretreatment assessment before safely initiating standard disease-modifying antirheumatic drugs (DMARDs) like methotrexate, which is strictly contraindicated in cases of liver disease or severe kidney impairment (Cohen & Mikuls, 2025

doi: 10.3748/wjg.v30.i9.1073

For acne, lower-dose isotretinoin may be appropriate for patients who: Are highly sensitive to side effects Require prolonged treatment Have difficulty tolerating standard doses For GLP-1 medications, lower dosing within approved ranges may be reasonable if a patient is responding well